Tetracyclines probably penetrate bacterial cells by passive diffusion and inhibit bacterial growth by interfering with protein synthesis or by destroying the membrane.
Error message | View complete answer on https://pubmed.ncbi.nlm.nih.gov
Table of Contents
How does tetracycline affect bacteria?
Tetracyclines prevent the growth of bacteria by inhibiting protein synthesis and they have broad-spectrum activity against Gram-positive and Gram-negative bacteria.
Error message | View complete answer on https://www.sciencedirect.com
How does tetracycline stop bacteria from dividing?
Tetracycline can cross the membranes of bacteria and accumulate in high concentrations in the cytoplasm. Tetracycline then binds to a single site on the ribosome–the 30S (smaller) ribosomal subunit–and blocks a key RNA interaction, which shuts off the lengthening protein chain.
Error message | View complete answer on https://www.scientificamerican.com
How does tetracycline prevent bacterial growth?
Tetracyclines probably penetrate bacterial cells by passive diffusion and inhibit bacterial growth by interfering with protein synthesis or by destroying the membrane. A growing number of various bacterial species acquire resistance to the bacteriostatic activity of tetracycline.
Error message | View complete answer on https://pubmed.ncbi.nlm.nih.gov
What is the mechanism of action of tetracycline on bacteria?
Once inside the cell, tetracyclines bind reversibly to the 30S ribosomal subunit at a position that blocks the binding of the aminoacyl-tRNA to the acceptor site on the mRNA-ribosome complex. Protein synthesis is ultimately inhibited, leading to a bacteriostatic effect [2].
Error message | View complete answer on https://www.uptodate.com
How does the antibiotic tetracycline inhibit bacterial but not host cell growth?
They inhibit protein synthesis in both bacterial and human cells. Bacteria have a system that allows tetracyclines to be transported into the cell, whereas human cells do not; human cells therefore are spared the effects of tetracycline on protein synthesis.
Error message | View complete answer on https://www.britannica.com
What does tetracycline prevent from binding?
It has been established that the tetracyclines inhibit bacterial protein synthesis by inhibiting the binding of aminoacyl-tRNA to the mRNA-ribosome complex (7, 8, 39, 51).
Error message | View complete answer on https://www.ncbi.nlm.nih.gov
What effect does tetracycline have on bacteria?
Tetracyclines probably penetrate bacterial cells by passive diffusion and inhibit bacterial growth by interfering with protein synthesis or by destroying the membrane. A growing number of various bacterial species acquire resistance to the bacteriostatic activity of tetracycline.
Error message | View complete answer on https://pubmed.ncbi.nlm.nih.gov
How does tetracycline fight bacteria?
Tetracyclines preferentially bind to bacterial ribosomes and interact with a highly conserved 16S ribosomal RNA (rRNA) target in the 30S ribosomal subunit, arresting translation by sterically interfering with the docking of aminoacyl-transfer RNA (tRNA) during elongation (Maxwell 1967; Brodersen et al.
Error message | View complete answer on https://www.ncbi.nlm.nih.gov
How does tetracycline stop bacteria from dividing?
Tetracycline can cross the membranes of bacteria and accumulate in high concentrations in the cytoplasm. Tetracycline then binds to a single site on the ribosome–the 30S (smaller) ribosomal subunit–and blocks a key RNA interaction, which shuts off the lengthening protein chain.
Error message | View complete answer on https://www.scientificamerican.com
What does tetracycline target in a bacterial cell?
They target the ribosomal machinery within the bacteria that assembles proteins from amino acids. Due to this mode of action, tetracyclines inhibit bacterial growth rather than killing them. Tetracyclines prohibit protein synthesis in both human and bacterial cells.
Error message | View complete answer on https://www.rxlist.com
